منابع مشابه
CD137 expression in tumor vessel walls. High correlation with malignant tumors.
CD137 (ILA/4-1BB), a member of the tumor necrosis factor receptor family, and its ligand are expressed on activated T lymphocytes and on antigen-presenting cells, respectively. Via bidirectional signal transduction, this receptor-ligand system regulates the activation, proliferation, and survival of T and B lymphocytes and monocytes. We used immunohistochemical studies on human tissue samples t...
متن کاملCD137 is expressed on blood vessel walls at sites of inflammation and enhances monocyte migratory activity.
The cytokine receptor CD137 is a member of the TNF receptor family and a potent T cell costimulatory molecule. Its ligand is expressed on antigen presenting cells as a transmembrane protein and it too can deliver signals into the cells it is expressed on (reverse signaling). In monocytes, immobilized CD137 protein induces activation, prolongation of survival and proliferation. Here we show that...
متن کاملExpression of CD137 and CD137 ligand in colorectal cancer patients.
The cytokine CD137, a member of the TNF receptor family, is expressed by T cells and regulates activation and proliferation of these cells. The CD137 ligand (CD137L) is expressed by antigen-presenting cells including macrophages, but also on various carcinoma cells. CD137/CD137L interaction plays a central role in sustaining T cell and macrophage activation, i.e. in antitumour immunity. The pre...
متن کاملDisease-associated prion protein in vessel walls.
Human prion diseases like Creutzfeldt-Jakob disease are infectious, inherited, or sporadic neurodegenerative disorders, characterized by the accumulation of an abnormal isoform of the host-encoded prion protein. This affects nervous tissue in sporadic Creutzfeldt-Jakob disease and, additionally, in lymphoid tissue in bovine spongiform encephalopathy-linked variant Creutzfeldt-Jakob disease. Exp...
متن کاملHigh Resolution MR of Arterial Vessel Walls
A new high-resolution MR (HR-MR) black-blood imaging technique has been developed that enables examination of intra-cranial arterial vessel walls. HR-MR images can show arterial wall thickening (concentric or asymmetric), atherosclerotic plaque, intramural hemorrhage, and enhancement. HR-MR shows promise for the diagnosis of several cerebrovascular diseases: Atherosclerosis Arteritis Reversible...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: American Journal of Clinical Pathology
سال: 2001
ISSN: 0002-9173,1943-7722
DOI: 10.1309/e343-kmyx-w3y2-10ky